Key result
A 40-year-old female with incidentally discovered hepatic epithelioid hemangioendothelioma successfully underwent orthotopic liver transplantation after being deemed ineligible for resection.
Why the study?
Hepatic epithelioid hemangioendothelioma is an exceedingly rare vascular tumor that is misidentified in up to 80% of cases.
Case Report (n=1)
Highlights a rare case of hepatic epithelioid hemangioendothelioma discovered incidentally on CT, emphasizing the diagnostic challenge of this vascular tumor.
Hepatic epithelioid hemangioendothelioma (HEHE) is an exceedingly rare vascular tumor first described by Weiss and Enzinger in 1982.1 It is a neoplasm that can arise in many different parts of the body, but most frequently involves the liver, lung, and bone.2 It disproportionately affects females with a ratio of 3:2 and 50% of cases are discovered incidentally. HEHE is misidentified in up to 80% of cases. It can be mistaken for angiosarcoma, metastatic carcinoma, hepatocellular carcinoma (HCC), or cholangiocarcinoma. While 25 – 40% of patients are asymptomatic, common presenting symptoms include right upper-quadrant pain, fatigue, nausea, vomiting, weakness, ascites, anorexia, and weight loss.2–4 Up to 37% of patients have distant metastases at the time of diagnosis and rapid progression is seen in up to 75% of cases where there are multifocal lesions.2,4 This report presents a unique case of HEHE found incidentally on computerized tomography (CT).
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Johnson et al. (2021) conducted a case report in Hepatic Epithelioid Hemangioendothelioma (n=1). Orthotopic liver transplantation was evaluated on Clinical outcome. A 40-year-old female with incidentally discovered hepatic epithelioid hemangioendothelioma successfully underwent orthotopic liver transplantation after being deemed ineligible for resection.
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