Key result
Treatment with valsartan significantly decreased vascular injury parameters in wild-type mice, with greater inhibitory effects in females, a difference that was attenuated in AT2 receptor-null mice.
Why the study?
Does valsartan treatment and AT2 receptor expression explain sex differences in vascular injury response in mice?
Does valsartan treatment and AT2 receptor expression explain sex differences in vascular injury response in mice?
Sex differences in response to vascular injury and the vasoprotective effects of valsartan are partially attributed to exaggerated AT2 receptor expression in female mice.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for AT2-mediated sex differences in ARB vascular effects; should not yet change clinical practice.
Okumura et al. (2005) studied Vascular injury. Valsartan vs. Untreated / Male mice was evaluated on Vascular remodeling parameters (neointimal formation, DNA synthesis, MCP-1 expression, superoxide anion production, NADPH oxidase activity). Treatment with valsartan significantly decreased vascular injury parameters in wild-type mice, with greater inhibitory effects in females, a difference that was attenuated in AT2 receptor-null mice.
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