Sex-Specific Disparities in Outcomes of Transcatheter Edge-to-Edge Repair for Mitral Regurgitation: A Multicenter “Real-World” Analysis
Key result
Female sex was associated with significantly better 3-year survival compared to male sex after transcatheter edge-to-edge repair for mitral regurgitation (60.7% vs. 54.2%; HR 0.8, 95% CI 0.6-0.9).
Why the study?
Sex differences in outcomes are evident after surgical mitral regurgitation treatment, but data regarding sex-specific outcomes following transcatheter edge-to-edge repair remain limited and conflicting.
Does female sex impact procedural safety, efficacy, and long-term survival compared to male sex in patients undergoing transcatheter edge-to-edge repair for mitral regurgitation?
Population
821 patients undergoing TEER for mitral regurgitation
Comparison
Female vs male patients
Design
Multicenter observational cohort study
Follow-up
3 years
Authors
Discussion
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Member takes
Implication
Women show similar TEER safety but better adjusted long-term survival than men; observational data leave open whether sex- or AF-tailored strategies are needed.
Study Design
Type
Cohort (n=821)
Multicenter
Yes
Structured PICO
Does female sex impact procedural safety, efficacy, and long-term survival compared to male sex in patients undergoing transcatheter edge-to-edge repair for mitral regurgitation?
P
Population
821 patients (37.4% female) undergoing transcatheter edge-to-edge repair for mitral regurgitation, evaluated for sex-specific outcomes over 3 years.
E
Exposure
Transcatheter edge-to-edge repair (TEER) in female patients
C
Comparator
Transcatheter edge-to-edge repair (TEER) in male patients
O
Outcome
Procedural safety and efficacy, in-hospital mortality, and long-term survival (3 years)hard clinical
Main Result
Hazard Ratio: 0.8 (95% CI 0.6–0.9)
Absolute Event Rate: 60.7% vs 54.2%
p-value: p=0.02
Female patients undergoing TEER for mitral regurgitation exhibit better long-term survival than males, although concomitant atrial fibrillation negates this survival advantage.
Cite This Study
Ausbuettel et al. (2023) conducted a cohort in Mitral regurgitation (n=821). Female sex vs. Male sex was evaluated on All-cause death at 3 years (HR 0.8, 95% CI 0.6-0.9, p=0.02). Female sex was associated with significantly better 3-year survival compared to male sex after transcatheter edge-to-edge repair for mitral regurgitation (60.7% vs. 54.2%; HR 0.8, 95% CI 0.6-0.9).