Key result
Women with a history of gestational diabetes mellitus based on WHO criteria had significantly higher arterial stiffness (PWV 6.9 vs 6.6 m/s) and more severe dyslipidemia at 5-year follow-up compared to women without GDM.
Why the study?
Does a history of gestational diabetes mellitus increase arterial stiffness and dyslipidemia in women 5 years post-pregnancy?
Population
300 women from the original STORK study, evaluated 5 years after their index pregnancy
Comparison
History of Gestational Diabetes Mellitus… vs Women without a history of GDM
Design
Cohort
Follow-up
5 years
Authors
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May support enhanced postpartum CV risk assessment after GDM; hypothesis-generating for targeted interventions on arterial stiffness.
Cohort (n=300)
No
Does a history of gestational diabetes mellitus increase arterial stiffness and dyslipidemia in women 5 years post-pregnancy?
Absolute Event Rate: 6.9% vs 6.6%
p-value: p=0.046
A history of gestational diabetes mellitus (by WHO criteria) is associated with increased arterial stiffness and dyslipidemia 5 years post-pregnancy, indicating elevated future cardiovascular risk.
Lekva et al. (2015) conducted a cohort in Gestational Diabetes Mellitus (n=300). History of Gestational Diabetes Mellitus (WHO criteria) vs. No history of Gestational Diabetes Mellitus was evaluated on Pulse wave velocity (PWV) at 5-year follow-up (p=0.046). Women with a history of gestational diabetes mellitus based on WHO criteria had significantly higher arterial stiffness (PWV 6.9 vs 6.6 m/s) and more severe dyslipidemia at 5-year follow-up compared to women without GDM.
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