Key result
Diabetic metabolic aberrations accelerate peripheral arterial disease progression through glycation, LDL, and oxidative stress.
Answers are grounded in this paper and cite their sources.
Peripheral arterial disease (PAD) increases the risk of lower extremity amputation. It is also an independent predictor of cardiovascular and cerebrovascular ischemic events, affecting both the quality and expectancy of life. Many studies have demonstrated that the prevalence of PAD in patients with diabetes mellitus (DM) is higher than in non-diabetic patients. In diabetic patients, PAD occurs early with rapid progression, and is frequently asymptomatic. Multiple metabolic aberrations in DM, such as advanced glycation end-products, low-density lipoprotein cholesterol, and abnormal oxidative stress, have been shown to worsen PAD. However, the role of DM in PAD is not completely understood. The purpose of the present article is to review and discuss the pathophysiology of PAD in DM.
No takes yet. Share an insight, caveat, or question.
Yang et al. (2016) conducted a review in Peripheral arterial disease in diabetes mellitus. Diabetes mellitus and associated metabolic aberrations (advanced glycation end-products, LDL cholesterol, abnormal oxidative stress) vs. Non-diabetic patients was evaluated on Pathophysiology and progression of peripheral arterial disease. Metabolic aberrations in diabetes mellitus—including advanced glycation end-products, LDL cholesterol, and abnormal oxidative stress—worsen peripheral arterial disease and accelerate its progression.
Synapse has enriched 10 related papers. Consider them for comparative context: