Key result
A reporter gene construct under the control of a matrix metalloproteinase-1 promoter allowed real-time, non-invasive in vivo bioluminescence imaging of bleomycin-induced lung fibrosis in mice.
p-value: p=<0.01
The use of a heterologous MMP-1 gene promoter reporter construct enables real-time, non-invasive in vivo imaging of bleomycin-induced lung fibrosis in mice.
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Enables non-invasive longitudinal fibrosis monitoring in bleomycin mice; leaves open whether this approach improves translational IPF research.
Stellari et al. (2017) studied Idiopathic pulmonary fibrosis (experimental model). Bleomycin and pbMMP-1-Luc reporter gene vs. Saline was evaluated on In vivo bioluminescence imaging of MMP-1 promoter activity (p=<0.01). A reporter gene construct under the control of a matrix metalloproteinase-1 promoter allowed real-time, non-invasive in vivo bioluminescence imaging of bleomycin-induced lung fibrosis in mice.
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