Why the study?
Does the SLe(x) analogue CY-1503 reduce myocardial infarct size in a canine model of ischemia and reperfusion?
Population
Anesthetized mongrel dogs subjected to 90 minutes of ischemia through occlusion of the left anterior…
Comparison
SLe analogue CY-1503 at a dose of 20 mg/kg… vs Normal saline
Design
Preclinical
Follow-up
48 hours
Authors
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CY-1503 does not reduce infarct size in this canine model; leaves open SLe(x) analogue efficacy in other species or humans.
Does the SLe(x) analogue CY-1503 reduce myocardial infarct size in a canine model of ischemia and reperfusion?
The SLe(x) analogue CY-1503 did not significantly reduce myocardial infarct size or neutrophil accumulation in a canine model of ischemia and reperfusion.
Gill et al. (1996) studied this question.
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