August 1, 1985Journal of Applied Physiology

Specificity and sensitivity of noninvasive measurement of pulmonary vascular protein leak

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Why the study?

Does a noninvasive double-radioisotope method accurately and specifically measure pulmonary vascular protein leak in anesthetized dogs?

Population

Anesthetized dogs

Comparison

Noninvasive double-radioisotope measurement of… vs Hydrostatic edema vs lung injury edema vs controls

Design

Preclinical

Follow-up

150 min

Authors

IDI M DauberUniversity of Colorado Hospital WPW. T. Pluss AVA. VanGrondelle

Discussion

Member takes

Implication

Supports noninvasive lung leak assessment in animal models; leaves open human translation and clinical adoption.

Structured PICO

Does a noninvasive double-radioisotope method accurately and specifically measure pulmonary vascular protein leak in anesthetized dogs?

Population

Anesthetized dogs

Intervention

Noninvasive double-radioisotope measurement of pulmonary vascular protein leak using radiolabeled albumin (131I) and erythrocytes (99mTc) with external gamma probe counting

Comparator

Hydrostatic edema (elevated left atrial pressure) vs lung injury edema (high-dose 1.0 g/kg and low-dose 0.25 g/kg intravenous thiourea) vs controls

Outcome

Albumin leak index and gravimetric lung watersurrogate

A noninvasive double-radioisotope method is specific for lung injury and sensitive enough to detect injury before measurable pulmonary edema occurs.

Cite This Study

Dauber et al. (1985) studied this question.

synapsesocial.com/papers/6a792bd52eb3c7e469f3679b https://doi.org/10.1152/jappl.1985.59.2.564

Topics

Sermorelin

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August 1, 1985Journal of Applied Physiology

Specificity and sensitivity of noninvasive measurement of pulmonary vascular protein leak

View Full Paper

Ask AI

Bookmark

Why the study?

Does a noninvasive double-radioisotope method accurately and specifically measure pulmonary vascular protein leak in anesthetized dogs?

Population

Anesthetized dogs

Comparison

Noninvasive double-radioisotope measurement of… vs Hydrostatic edema vs lung injury edema vs controls

Design

Preclinical

Follow-up

150 min

Authors

IDI M DauberUniversity of Colorado Hospital WPW. T. Pluss AVA. VanGrondelle

Discussion

Member takes

Implication

Supports noninvasive lung leak assessment in animal models; leaves open human translation and clinical adoption.

Structured PICO

Does a noninvasive double-radioisotope method accurately and specifically measure pulmonary vascular protein leak in anesthetized dogs?

Population

Anesthetized dogs

Intervention

Noninvasive double-radioisotope measurement of pulmonary vascular protein leak using radiolabeled albumin (131I) and erythrocytes (99mTc) with external gamma probe counting

Comparator

Hydrostatic edema (elevated left atrial pressure) vs lung injury edema (high-dose 1.0 g/kg and low-dose 0.25 g/kg intravenous thiourea) vs controls

Outcome

Albumin leak index and gravimetric lung watersurrogate

A noninvasive double-radioisotope method is specific for lung injury and sensitive enough to detect injury before measurable pulmonary edema occurs.

Cite This Study

Dauber et al. (1985) studied this question.

synapsesocial.com/papers/6a792bd52eb3c7e469f3679b https://doi.org/10.1152/jappl.1985.59.2.564

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Sermorelin

View Full Paper

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