Key result
Persistent hypertriglyceridemia significantly increased the risk of early-onset colorectal cancer (aHR 1.097) compared to persistent normotriglyceridemia in young adults.
Why the study?
The incidence of early-onset colorectal cancer is increasing worldwide, but the association between hypertriglyceridemia and early-onset colorectal cancer risk remains unclear.
Does persistent hypertriglyceridemia increase the risk of early-onset colorectal cancer in individuals aged 20-49 years?
Cohort (n=3,340,635)
Yes
Does persistent hypertriglyceridemia increase the risk of early-onset colorectal cancer in individuals aged 20-49 years?
Hazard Ratio: 1.097 (95% CI 1.025–1.174)
Absolute Event Rate: 0.406% vs 0.364%
Persistent hypertriglyceridemia is associated with a modestly increased risk of early-onset colorectal cancer, particularly rectal cancer, in young adults.
PURPOSE: The incidence of early-onset colorectal cancer (EoCRC) is increasing worldwide. The association between hypertriglyceridemia (HTG) and EoCRC risk remains unclear. MATERIALS AND METHODS: We conducted a nationwide cohort study of 3,340,635 individuals aged 20-49 years who underwent health checkups between 2009 and 2011 under the Korean National Health Insurance Service. HTG was defined as serum triglyceride (TG) level ≥ 150 mg/dL. According to the change in TG status, participants were categorized into persistent normotriglyceridemia (NTG; group 1), NTG to HTG (group 2), HTG to NTG (group 3), and persistent HTG (group 4) groups. The EoCRC incidence was followed up until 2019. RESULTS: In total, 7,492 EoCRC cases developed after a mean of 6.05 years of follow-up. Group 4 had the highest risk of EoCRC (adjusted hazard ratio [aHR], 1.097; 95% confidence interval [CI], 1.025 to 1.174). While the risk of rectal cancer was significantly increased in groups 3 and 4 (aHR [95% CI], 1.236 [1.076 to 1.419] and 1.175 [1.042-1.325], respectively), no significant risk differences were observed in right colon cancer. In group 4, male sex and diabetes were associated with a further increased risk of EoCRC (aHR [95% CI], 1.149 [1.082 to 1.221] and 1.409 [1.169 to 1.699], respectively). In addition, there was a dose-response relationship between serum TG levels and the risk of EoCRC (p for trends < 0.0001). CONCLUSION: Persistent HTG increased the risk of EoCRC, which was significantly higher only for rectal cancer and marginally higher for other colonic subsites.
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Chang et al. (2023) conducted a cohort in Early-onset colorectal cancer (n=3,340,635). Persistent hypertriglyceridemia vs. Persistent normotriglyceridemia was evaluated on Incidence of newly diagnosed early-onset colorectal cancer (EoCRC) (aHR 1.097, 95% CI 1.025-1.174). Persistent hypertriglyceridemia significantly increased the risk of early-onset colorectal cancer (aHR 1.097) compared to persistent normotriglyceridemia in young adults.
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