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May 25, 2018Open Access

Contemporary circulating enterovirus D68 strains show differential viral entry and replication in human neuronal cells

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Population

SH-SY5Y neuroblastoma-derived neuronal cell line, HeLa cells, A549 cells, primary human neuron cultures, and…

Design

Preclinical

Key result

Contemporary EV-D68 strains demonstrated neurotropism by replicating in human neuronal cells and causing paralysis in mice, whereas historical strains did not.

Authors

DBDavid BrownAHAlison M. HixonLOLauren M. Oldfield

Discussion

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Overview

May link recent EV-D68 strains to AFM via neuronal tropism; leaves open causal confirmation in vivo.

Structured PICO

P
Population
In vitro human neuronal cell lines (SH-SY5Y) and in vivo neonatal mouse models used to study enterovirus D68 neurotropism.
E
Exposure
Infection with different contemporary EV-D68 strains (including 2014 outbreak strains)
O
Outcome
Viral replication and infectivity (assessed via infectious virus production, cytopathic effects, cellular ATP release, and VP1 capsid protein production)surrogate

A subset of contemporary EV-D68 strains demonstrate neurotropism in neuronal cell models, driven partly by viral entry barriers, supporting a potential causal link to acute flaccid myelitis.

Cite This Study

Brown et al. (2018) studied Enterovirus D68 infection. Contemporary EV-D68 strains vs. Historical EV-D68 strains was evaluated on Viral replication in neuronal cells and induction of paralysis in mice. Contemporary EV-D68 strains demonstrated neurotropism by replicating in human neuronal cells and causing paralysis in mice, whereas historical strains did not.

synapsesocial.com/papers/6a792fee8a3ae1c742320ae1https://doi.org/10.1101/331116
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  5. 5High frequency of enterovirus D 68 in children hospitalised with respiratory illness in N orway, autumn 20142014 · 73 citations