Key result
Filamin C is a highly dynamic protein that is immediately recruited to sarcomeric lesions, enabling the repair of damaged myofibrils within 4 hours even without de novo protein synthesis.
Population
Cultured neonatal mouse cardiomyocytes, cardiac and skeletal muscles of live transgenic zebrafish embryos…
Design
Preclinical
Authors
Loading...
Filamin C may aid rapid cardiomyocyte repair; animal data leave open therapeutic relevance in human cardiac injury.
Filamin C acts as a highly dynamic signaling hub that is immediately recruited to repair myofibrillar microdamage in cardiomyocytes, providing insight into early stages of FLNc-related myopathies.
Leber et al. (2016) studied Myofibrillar microdamage. Photobleaching and myofibrillar microdamage assay was evaluated on Repair of damaged myofibrils. Filamin C is a highly dynamic protein that is immediately recruited to sarcomeric lesions, enabling the repair of damaged myofibrils within 4 hours even without de novo protein synthesis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: