Key result
Typical (OR 3.94; 95% CI 2.05-7.55) and atypical antipsychotics (OR 4.36; 95% CI 2.54-7.51), and SSRIs (OR 2.21) were strongly associated with sudden death.
Why the study?
Do noncardiac drugs tending to prolong the QT interval increase the risk of sudden death in the community?
Population
1010 patients dying suddenly where post-mortem examination did not identify a clear cause of death, and 3030…
Comparison
Drugs grouped by their risk of causing torsades… vs Matched living controls from primary care
Design
Case-control
Authors
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Supports caution with antipsychotics and SSRIs; leaves open whether QT prolongation predicts community sudden death.
Case-Control (n=4,040)
Do noncardiac drugs tending to prolong the QT interval increase the risk of sudden death in the community?
Odds Ratio: 3.94 (95% CI 2.05–7.55)
Typical and atypical antipsychotics, as well as SSRIs, are strongly associated with an increased risk of sudden death, whereas the Arizona classification of TdP risk is a poor predictor of noncardiac drug-associated sudden death.
Jolly et al. (2009) conducted a case-control in Sudden death (n=4,040). Drugs tending to prolong the QT interval (antipsychotics, antidepressants) vs. Matched living controls was evaluated on Sudden death (OR 3.94, 95% CI 2.05-7.55). Typical (OR 3.94; 95% CI 2.05-7.55) and atypical antipsychotics (OR 4.36; 95% CI 2.54-7.51), and SSRIs (OR 2.21) were strongly associated with sudden death.
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