Key result
Following myocardial infarction in mice, circulating IL-18 was significantly elevated compared to sham (90.4 vs 47.2 pg/ml, P<0.001), suggesting a role in post-ischemic contractile dysfunction.
Why the study?
Does IL-18 reduce myocardial contractility in mice following myocardial infarction?
Population
Mice with induced myocardial infarction and sham-operated controls, as well as electrically stimulated adult…
Comparison
Induction of myocardial infarction. vs Sham operation.
Design
Preclinical
Follow-up
7 days
Authors
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May link IL-18 to post-MI dysfunction in mice; hypothesis-generating and should not yet change practice.
Does IL-18 reduce myocardial contractility in mice following myocardial infarction?
Absolute Event Rate: 90.4% vs 47.2%
p-value: p=<0.001
Increased production of IL-18 after myocardial infarction in mice may contribute to post-ischemic contractile dysfunction.
Per Reidar Woldbæk (2003) studied Myocardial infarction. Myocardial infarction vs. Sham was evaluated on Circulating IL-18 concentration (pg/ml) (p=<0.001). Following myocardial infarction in mice, circulating IL-18 was significantly elevated compared to sham (90.4 vs 47.2 pg/ml, P<0.001), suggesting a role in post-ischemic contractile dysfunction.
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