Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells.
Population
Bovine chromaffin cells
Comparison
Trifluoperazine in concentrations up to 10 microM vs Controls (absence of TFP)
Design
Preclinical
Authors
Discussion
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Implication
TFP's intracellular exocytosis inhibition in bovine cells should not change practice; leaves open translation to mammalian neurons or therapeutics.
Structured PICO
P
Population
Bovine chromaffin cells
I
Intervention
Trifluoperazine (TFP) in concentrations up to 10 microM
C
Comparator
Controls (absence of TFP)
O
Outcome
Unitary inward currents (Na, Ca, and acetylcholine-induced) and stimulus-evoked increments in membrane capacitancesurrogate
Trifluoperazine prevents exocytosis in bovine chromaffin cells through intracellular actions independent of its inhibition of electrical excitability.
Cite This Study
Clapham et al. (1984) studied this question.