Key result
Maternal preeclampsia was associated with significantly lower left ventricle end-diastolic dimension and peak E/A ratio in premature infants, indicating early diastolic dysfunction.
Why the study?
Does maternal preeclampsia affect left ventricular diastolic function and neonatal morbidity in premature infants?
Cohort (n=95)
No
Does maternal preeclampsia affect left ventricular diastolic function and neonatal morbidity in premature infants?
Premature infants born to preeclamptic mothers exhibit early left ventricular diastolic dysfunction, which is associated with increased respiratory morbidity and intrauterine growth retardation.
May warrant echocardiographic monitoring in affected preterm infants; hypothesis-generating for respiratory morbidity links and prospective trials.
AIM: To evaluate the cardiac function in premature infants born to preeclamptic mothers and its clinical consequences. METHODS: This was a prospective observational cohort study performed in a tertiary neonatal intensive care unit. Fifty-three premature infants born to preeclamptic mothers comprising the study group were evaluated and compared with 42 premature infants born to normotensive mothers (control group). Relationship between echocardiographic measures and neonatal morbidity were assessed as the main outcome measures. RESULTS: Left ventricle end-diastolic dimension (LVEDD), peak flow velocities during early diastole (peak E wave), peak flow velocities during atrial contraction (peak A wave), and peak E/A ratio were significantly lower in the study group. Within the study group, these parameters were also significantly lower in infants with respiratory problems. LVEDD was significantly smaller in preeclamptic infants with intrauterine growth retardation (IUGR). CONCLUSION: Left ventricle diastolic dysfunction (LVDD) was detected in premature infants born to preeclamptic mothers in the first week after delivery. LVDD was associated with higher incidence of respiratory problems, transient tachypnea of the newborn, longer duration of oxygen requirement, and IUGR.
No takes yet. Share an insight, caveat, or question.
Çetınkaya et al. (2010) conducted a cohort in Premature infants (n=95). Maternal preeclampsia vs. Maternal normotension was evaluated on Relationship between echocardiographic measures and neonatal morbidity. Maternal preeclampsia was associated with significantly lower left ventricle end-diastolic dimension and peak E/A ratio in premature infants, indicating early diastolic dysfunction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: