Key result
The use of biosensors and fluorescence microscopy to measure NO in living endothelial cells revealed discordance between eNOS phosphorylation and activation.
Why the study?
The high reactivity of NO undermines its accurate detection in living cells, making the direct detection of low physiological concentrations in endothelial cells a significant analytical challenge.
Advanced biosensor imaging in living endothelial cells reveals discordance between eNOS phosphorylation and activation, challenging previous models of eNOS regulation.
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Eroğlu et al. (2019) studied this question. Multispectral imaging and chemogenetic methods was evaluated on Measurement of NO and key signaling molecules in living endothelial cells. The use of biosensors and fluorescence microscopy to measure NO in living endothelial cells revealed discordance between eNOS phosphorylation and activation.
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