Do Bone Marrow Cells Generate Neurons?

n the past 5 years, accumulating evidence has demonstrated plasticity of bone marrowderived cells.Bone marrow-derived cells display the capacity to change their fate, differentiating into hepatocytes, endothelial cells, muscle cells, and cardiomyocytes, and even neurons. 1The findings that bone marrow cells differentiate into neurons in vitro and in vivo challenge previous assumptions that tissue-specific stem cells give rise only to cells of their organ of origin and do not cross lineages.