Key result
Pretreatment with clopidogrel before primary PCI for STEMI significantly improved initial patency compared to no pretreatment (34.3% vs 25.8%; OR 1.51; 95% CI 1.31-1.74; P<0.0001).
Why the study?
Does pretreatment with clopidogrel improve initial patency and clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention?
Meta-Analysis (n=8,429)
Does pretreatment with clopidogrel improve initial patency and clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention?
Odds Ratio: 1.51 (95% CI 1.31–1.74)
Absolute Event Rate: 34.3% vs 25.8%
p-value: p=<0.0001
Pretreatment with clopidogrel before primary PCI in STEMI patients significantly improves initial infarct-related artery patency and clinical outcomes.
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Supports clopidogrel pretreatment to improve initial patency before primary PCI in STEMI; confirms benefit in meta-analysis of trials.
Vlaar et al. (2008) conducted a meta-analysis in ST-segment elevation myocardial infarction (n=8,429). Pretreatment with clopidogrel vs. No clopidogrel before initial coronary angiography was evaluated on Initial patency / early reperfusion (OR 1.51, 95% CI 1.31 to 1.74, p=<0.0001). Pretreatment with clopidogrel before primary PCI for STEMI significantly improved initial patency compared to no pretreatment (34.3% vs 25.8%; OR 1.51; 95% CI 1.31-1.74; P<0.0001).
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