What is the clinical evidence from this study?

Study design: Cohort. Population: Postinfarction ventricular septal rupture (n=109). Intervention: Incomplete coronary revascularization vs. Complete coronary revascularization. Primary outcome: Late cardiac mortality (p=0.024).

What does this research mean for the field?

Concomitant complete coronary revascularization during surgical repair of postinfarction ventricular septal rupture improves late survival, as incomplete revascularization is a significant risk factor for late cardiac mortality. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to evaluate the role of coronary revascularization in late survival after postinfarction ventricular septal rupture.

August 10, 2026European Heart JournalOpen Access

Importance of coronary revascularization for late survival after postinfarction ventricular septal rupture: A reason to perform coronary angiography prior to surgery

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Key result

Incomplete coronary revascularization is linked to higher late cardiac mortality after ventricular septal rupture repair.

P=0.024
n=109

Why the study?

Data on coronary artery pathology in postinfarction ventricular septal rupture were inconsistent, and the benefits and risks of preoperative coronary angiography and subsequent CABG remained under discussion.

Does concomitant complete coronary revascularization improve late survival in patients undergoing surgical repair of postinfarction ventricular septal rupture?

Population

109 consecutive patients surgically treated for postinfarction ventricular septal rupture

Comparison

Coronary revascularization in addition to surgical closure vs surgical closure alone

Design

Observational cohort study

Authors

FCFrank F. CoxSt. Antonius Ziekenhuis HPH. W. M. PlokkerSt. Antonius Ziekenhuis WMWim J. MorshuisRadboud University Nijmegen

Discussion

Member takes

Implication

Incomplete revascularization predicts higher late mortality after postinfarction VSR repair; leaves open whether adding it improves outcomes.

Key Points

This study aims to evaluate the role of coronary revascularization in late survival after postinfarction ventricular septal rupture.
Analysed clinical and coronary angiographic factors in 109 patients treated surgically for ventricular septal rupture between 1980 and 1992.
Coronary angiography was performed on 104 patients, with complete analysis of 92 angiograms.
Factors were related to late cardiac mortality in 79 patients who survived the early postoperative period.
Single-vessel disease was present in 58 patients (55.8%) and multiple-vessel disease in 46 patients (44.2%).
Postoperative cardiac failure (P=0.0089), incomplete coronary revascularization (P=0.024), and longer aortic cross-clamp time (P=0.032) were significant risk factors for late cardiac mortality.
41.3% of patients underwent coronary revascularization in addition to surgical closure, indicating potential benefits for late survival.

Study Design

Type

Cohort (n=109)

Structured PICO

Does concomitant complete coronary revascularization improve late survival in patients undergoing surgical repair of postinfarction ventricular septal rupture?

Population

109 consecutive patients treated surgically for postinfarction ventricular septal rupture between 1980 and 1992.

Exposure

Concomitant complete coronary revascularization (coronary artery bypass grafting) during surgical closure of ventricular septal rupture.

Comparator

Incomplete coronary revascularization or surgical closure alone.

Outcome

Late cardiac mortality in patients surviving the early postoperative period.hard clinical

Main Result

p-value: p=0.024

Concomitant complete coronary revascularization during surgical repair of postinfarction ventricular septal rupture is associated with improved late survival.

Cite This Study

Cox et al. (1996) conducted a cohort in Postinfarction ventricular septal rupture (n=109). Incomplete coronary revascularization vs. Complete coronary revascularization was evaluated on Late cardiac mortality (p=0.024). Incomplete coronary revascularization was a significant risk factor for late cardiac mortality (P=0.024) in patients surviving the early postoperative period after ventricular septal rupture repair.

synapsesocial.com/papers/6a7943270fef338e6eb458b3 https://doi.org/10.1093/oxfordjournals.eurheartj.a014801

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Implication

Incomplete revascularization predicts higher late mortality after postinfarction VSR repair; leaves open whether adding it improves outcomes.

Importance of coronary revascularization for late survival after postinfarction ventricular septal rupture: A reason to perform coronary angiography prior to surgery

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Importance of coronary revascularization for late survival after postinfarction ventricular septal rupture: A reason to perform coronary angiography prior to surgery

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

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