Key result
A BNP level ≥500 pg/ml was an independent predictor of previously unknown left ventricular systolic dysfunction in patients admitted for acute exacerbation of COPD (OR 8.5).
Why the study?
Does BNP measurement detect previously unknown left ventricular systolic dysfunction in patients admitted for acute exacerbation of COPD?
Population
57 patients with no history of heart failure admitted for acute exacerbation of chronic obstructive…
Comparison
Brain natriuretic peptide measurement at admission vs Echocardiography (reference standard)
Design
Cohort
Authors
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BNP ≥500 pg/ml may aid detection of occult LV dysfunction in acute COPD exacerbation; hypothesis-generating, prospective trials needed before practice change.
Cohort (n=57)
No
Does BNP measurement detect previously unknown left ventricular systolic dysfunction in patients admitted for acute exacerbation of COPD?
Odds Ratio: 8.5 (95% CI 1.9–38.2)
p-value: p=0.005
BNP measurement at admission can help identify previously unknown left ventricular systolic dysfunction in patients presenting with acute exacerbation of COPD.
Gariani et al. (2011) conducted a cohort in Acute exacerbation of chronic obstructive pulmonary disease (COPD) (n=57). Brain natriuretic peptide (BNP) level ≥500 pg/ml vs. BNP <500 pg/ml was evaluated on Left ventricular systolic dysfunction (LVEF < 50%) (OR 8.5, 95% CI 1.9 to 38.2, p=0.005). A BNP level ≥500 pg/ml was an independent predictor of previously unknown left ventricular systolic dysfunction in patients admitted for acute exacerbation of COPD (OR 8.5).
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