February 16, 1990Science

Glucose, Sulfonylureas, and Neurotransmitter Release: Role of ATP-Sensitive K + Channels

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Population

Brain cells, specifically in the substantia nigra

Design

Preclinical

Authors

Discussion

Hypothesis-generating for nigral KATP-GABA signaling in metabolic stress; leaves open human relevance.

Population

Brain cells, specifically in the substantia nigra

Intervention

High glucose concentrations, antidiabetic sulfonylureas, ATP depletion, and anoxia

Outcome

KATP channel activity and gamma-aminobutyric acid (GABA) releasesurrogate

KATP channels in the brain modulate neurotransmitter release in response to metabolic changes such as hyper/hypoglycemia and ischemia.

Amoroso et al. (1990) studied this question.

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