Key result
Insulin resistance in obese and obese-diabetic rats is associated with the unbrowning of brown adipose tissue and impaired thermogenesis, likely due to dysregulation of GLUT4 transporters.
This review explores the relationship between insulin resistance and the development and function of brown and beige adipose tissue in obese and diabetic rat models.
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Offers no immediate clinical guidance; leaves open mechanistic links between insulin resistance and beige fat in obesity models.
via fat accretion in response to alterations in diet, environment, hormonal and pharmacologic regulation. In addition, activation of beige adipose tissue via pharmacologic, physiologic or hormonal means may also occur via the adrenergic-activated mitochondrial uncoupling protein-1 (UCP1) activity in a manner similar to that of BAT while retaining its multilocular lipid histologic distribution. The morphometric and biological functions of beige adipose tissue in obese and obese-NIDDM rats during over-and undernutrition are reviewed and discussed, with particular reference to the prevalence and role of insulin resistance in various strains of obese and obese non-insulin dependent diabetic (NIDDM) rats in association with brown and beige adipose tissue.
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A 2023 study conducted a review in Obesity and Insulin Resistance. Insulin resistance and obesity vs. Lean phenotype was evaluated. Insulin resistance in obese and obese-diabetic rats is associated with the unbrowning of brown adipose tissue and impaired thermogenesis, likely due to dysregulation of GLUT4 transporters.
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