Key result
Browning of white adipose tissue modulates metabolic homeostasis, offering potential therapies for obesity and T2D.
Understanding the mechanisms of white adipose tissue browning may offer new therapeutic targets for combating obesity and type 2 diabetes.
Does not support immediate clinical use in obesity or diabetes; leaves open whether browning pathways offer viable therapeutic targets.
Great progress has been made in our understanding of the browning process in white adipose tissue (WAT) in rodents. The recognition that i) adult humans have physiologically inducible brown adipose tissue (BAT) that may facilitate resistance to obesity and ii) that adult human BAT molecularly and functionally resembles beige adipose tissue in rodents, reignited optimism that obesity and obesity-related diabetes type 2 can be battled by controlling the browning of WAT. In this review the main cellular mechanisms and molecular mediators of browning of WAT in different physiological states are summarized. The relevance of browning of WAT in metabolic health is considered primarily through a modulation of biological role of fat tissue in overall metabolic homeostasis.
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Janković et al. (2017) conducted a review in Obesity and obesity-related diabetes type 2. Browning of white adipose tissue was evaluated. Browning of white adipose tissue modulates the biological role of fat tissue in overall metabolic homeostasis, offering potential therapeutic avenues for obesity and type 2 diabetes.
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