Synopsis. Responses of isolated, perfused hearts of Homarus americanus to brief, in? ternal application of extracts of pericardial organs (PO's) of Cancer borealis, or to 5hydroxytryptamine (5HT) are very similar over a thousand-fold range of concentration: an increase in rate and amplitude of beating. These reach their maxima after washing out has begun, and recover within ten minutes. External application is ineffective and the substances do not interact with effects of stretch stimulation. Intracellular record?
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Ian M. Cooke (1966) studied this question.
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