Summary. The British Standards Institution have produced a recommended testing procedure for toxicity of dental materials; this advocates the use of a zinc oxide—eugenol cement such as Kalzinol, as a bland control in deep cavities. In this study, Kalzinol was applied directly to the exposed pulps of germ‐free rat molar teeth. This resulted in pulpal inflammation in contact with the material; when dentine particles separated Kalzinol from the pulp, calcific repair tissue was observed without inflammation or necrosis. Further investigation is required into suitable control materials for use in toxicity testing of restorative and lining materials.
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Watts et al. (1987) studied this question.
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