What question did this study set out to answer?

To estimate the national prevalence rates of inherited and acquired neuromuscular diseases in adults to quantify total disease burden.

December 8, 2016NeurologyOpen Access

A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland

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Authors

SLStela LefterUniversity College Cork OHOrla HardimanUniversity College Dublin ARAisling RyanUniversity College Dublin

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Implication

Population-based study reports a combined neuromuscular disease prevalence of 62.6 per 100,000 in adults, highlighting a substantial burden requiring dedicated healthcare service planning.

Key Points

To estimate the national prevalence rates of inherited and acquired neuromuscular diseases in adults to quantify total disease burden.
Conducted a population-based epidemiologic study in the Republic of Ireland with point prevalence calculated for December 2013.
Identified adult cases using multiple ascertainment sources, gathering demographic, clinical, and diagnostic verification data, alongside an existing registry for amyotrophic lateral sclerosis.
Identified 2,641 adults, establishing an overall neuromuscular disease prevalence rate of 62.6 per 100,000 (95% CI 59.95–65.24).
The most common individual conditions were myasthenia gravis at 15.12 per 100,000 (95% CI 13.82–16.42), sporadic inclusion body myositis at 11.7 per 100,000 (95% CI 9.82–13.58), and Charcot-Marie-Tooth at 10.52 per 100,000 (95% CI 9.44–11.61).
Additional rates included amyotrophic lateral sclerosis at 7.20 per 100,000 (95% CI 6.34–8.15), myotonic dystrophy type I at 6.75 per 100,000 (95% CI 5.88–7.61), and chronic inflammatory demyelinating polyradiculoneuropathy at 5.87 per 100,000 (95% CI 5.06–6.68).

Cite This Study

Lefter et al. (2016) studied this question.

synapsesocial.com/papers/6a795158fbd9051d3b0dafe6 https://doi.org/10.1212/wnl.0000000000003504

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Implication

Population-based study reports a combined neuromuscular disease prevalence of 62.6 per 100,000 in adults, highlighting a substantial burden requiring dedicated healthcare service planning.

A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland

Discussion

Member takes

Implication

Key Points

Cite This Study

A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland

Discussion

Member takes

Implication

Key Points

Cite This Study

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