Plasma cardiac natriuretic peptide determination as a screening test for the detection of patients with mild left ventricular impairment.
Why the study?
Do plasma cardiac natriuretic peptides accurately detect mild left ventricular impairment in patients undergoing cardiac catheterisation?
Population
254 consecutive patients undergoing diagnostic left-sided cardiac catheterisation, including 128 with a…
Comparison
Measurement of plasma cardiac natriuretic peptides vs Angiographically determined left ventricular…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
BNP may aid LV dysfunction detection during catheterization; leaves open its screening utility given modest accuracy in this cross-sectional cohort.
Structured PICO
Do plasma cardiac natriuretic peptides accurately detect mild left ventricular impairment in patients undergoing cardiac catheterisation?
P
Population
254 consecutive patients undergoing diagnostic left-sided cardiac catheterisation, including 128 with a history of previous myocardial infarction, at a Norwegian central hospital.
I
Intervention
Measurement of plasma cardiac natriuretic peptides (atrial natriuretic factor, N-terminal pro-atrial natriuretic factor, and brain natriuretic peptide)
C
Comparator
Angiographically determined left ventricular ejection fraction and left ventricular end diastolic pressure measurement (reference standard)
O
Outcome
Diagnostic accuracy for detecting impaired left ventricular function (LVEDP ≥ 15 mm Hg, LVEF ≤ 45%, or combination) evaluated by area under the receiver operating characteristic (ROC) curvesurrogate
Plasma brain natriuretic peptide is a better indicator of left ventricular function than atrial natriuretic factor, though its overall diagnostic accuracy as a screening test in this population is modest.
Cite This Study
Omland et al. (1996) studied this question.