Endomyocardial biopsy is crucial for diagnosing Borrelia carditis in patients with severe LV dysfunction and negative serology, allowing for successful targeted antibiotic therapy.
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May support biopsy-guided antibiotics in seronegative Borrelia carditis with LV dysfunction; leaves open prospective validation.
BorreliovĂĄ karditida je pojem oznaÄujĂcĂ srdeÄnĂ postiĹženĂ zpĹŻsobenĂŠ infekcĂ spirochetou Borrelia burgdorferi. OnemocnÄnĂ se nejÄastÄji manifestuje arytmiemi, mĂŠnÄ Äasto perikarditidou nebo myokardiĂĄlnĂ dysfunkcĂ. AutoĹi popisujĂ pĹĂpad kardiomyopatie s tÄĹžkou systolickou dysfunkcĂ levĂŠ komory, vzniklĂŠ v dĹŻsledku borreliovĂŠ infekce myokardu. V diagnostice etiologickĂŠho agens byla rozhodujĂcĂ endomyokardiĂĄlnĂ biopsie s komplexnĂm patologickĂ˝m a mikrobiologickĂ˝m hodnocenĂm, neboĹĽ sĂŠrologickĂŠ vyĹĄetĹenĂ, povaĹžovanĂŠ jinak za zĂĄklad diagnostiky borreliovĂŠ infekce, neprokĂĄzalo pĹĂtomnost specifickĂ˝ch protilĂĄtek. CĂlenĂĄ lĂŠÄba cefalosporinovĂ˝m antibiotikem III. generace nĂĄslednÄ vedla k ĂşplnĂŠ restituci systolickĂŠ funkce levĂŠ komory. Tento pĹĂpad podtrhuje vĂ˝znam provedenĂ endomyokardiĂĄlnĂ biopsie u nemocnĂ˝ch s podezĹenĂm na zĂĄnÄtlivou kardiomyopatii.
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Kuchynka et al. (2007) studied this question.
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