Why the study?
Does cellular cardiomyoplasty improve survival and heart function in mice with myocardial injury?
Population
2-month-old male mice with cryoinjured left ventricular walls (n=153 for survival analysis)
Design
Preclinical
Follow-up
2 weeks (for engraftment)
Authors
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No immediate clinical implications; extends proof-of-concept for cellular cardiomyoplasty in murine myocardial injury.
Does cellular cardiomyoplasty improve survival and heart function in mice with myocardial injury?
Transplantation of embryonic cardiomyocytes improves heart function and survival following myocardial injury in a murine model, providing proof of principle for cellular cardiomyoplasty.
Roell et al. (2002) studied this question.
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