Why the study?
Does perindopril improve physical function and exercise capacity in elderly people with functional impairment but without heart failure?
Population
130 elderly adults with problems with mobility or functional impairment, who had no heart failure or left…
Comparison
Perindopril for 20 weeks vs Placebo for 20 weeks
Design
RCT, randomly assigned, double-blind
Follow-up
20 weeks
Authors
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Perindopril improves exercise capacity in elderly patients with functional impairment but no heart failure; extends ACE inhibitor benefits beyond established cardiac indications.
Does perindopril improve physical function and exercise capacity in elderly people with functional impairment but without heart failure?
In elderly patients with functional impairment but no heart failure, perindopril significantly improved exercise capacity (6-minute walking distance) and maintained health-related quality of life.
Sumukadas et al. (2007) studied this question.
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