What question did this study set out to answer?

Evaluate epidemiologic and mechanistic evidence regarding the relationship between vitamin D intake, serum metabolite levels, and colorectal cancer incidence.

March 1, 2004Nutrition and Cancer

Reviews: A Critical Review of Studies on Vitamin D in Relation to Colorectal Cancer

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Authors

WGWilliam B. GrantSunlight Nutrition and Health Research Center CGCedric F. GarlandUniversity of California, San Diego

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Implication

Literature review finds reduced colorectal cancer incidence with high total vitamin D and circulating metabolites, suggesting overall exposure outweighs dietary intake alone.

Key Points

Evaluate epidemiologic and mechanistic evidence regarding the relationship between vitamin D intake, serum metabolite levels, and colorectal cancer incidence.
Conducted a comprehensive literature search across epidemiologic studies examining dietary vitamin D, total vitamin D exposure, and serum 25(OH)D3 levels.
Assessed laboratory findings from in vitro and animal models to outline biological mechanisms of vitamin D and its analogues in cancer prevention.
Studies measuring combined vitamin D sources or serum 25(OH)D3 levels consistently show significantly lower colorectal cancer incidence among individuals with above-average levels.
Studies restricted solely to dietary vitamin D demonstrate inconsistent protective effects because diet provides only a fraction of total circulating vitamin D compared to solar UV-B cutaneous synthesis and supplements.

Cite This Study

Grant et al. (2004) studied this question.

synapsesocial.com/papers/6a795c182eb3c7e469f381d0 https://doi.org/10.1207/s15327914nc4802_1

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Implication

Literature review finds reduced colorectal cancer incidence with high total vitamin D and circulating metabolites, suggesting overall exposure outweighs dietary intake alone.

Reviews: A Critical Review of Studies on Vitamin D in Relation to Colorectal Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Reviews: A Critical Review of Studies on Vitamin D in Relation to Colorectal Cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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