Chemical synthesis study demonstrates efficient coupling of diazoesters with sulfonyl hydrazides, highlighting a mild route to alpha-carbonyl sulfones.
A facile synthesis of α-carbonyl sulfones has been accomplished by the cross-coupling of α-aryl-α-diazoesters with sulfonyl hydrazides in the presence of CuI and DBU. The reaction employs inexpensive and bench stable sulfonyl hydrazides as a sulfonyl source, and facilitates the migratory insertion with α-aryl-α-diazoesters under mild reaction conditions.
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Sharma et al. (2022) studied this question.
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