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This study investigates the expression profiles of microRNAs to identify their roles in thyroid papillary carcinomas.

MicroRNA deregulation in human thyroid papillary carcinomas

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This study investigates the expression profiles of microRNAs to identify their roles in thyroid papillary carcinomas.
Analyzed genome-wide miRNA expression using miRNACHIP microarray in thyroid papillary carcinomas.
Confirmed findings through northern blot and quantitative RT-PCR analyses.
Conducted functional studies by manipulating miR-221 expression in human PTC-derived cell lines.
Identified significant overexpression of miR-221, -222, and -181b in PTCs versus normal thyroid tissue.
MiRNA overexpression was also observed in fine needle aspiration biopsies of thyroid nodules diagnosed as papillary carcinomas.
Functional studies indicated that miR-221 overexpression plays a critical role in thyroid carcinogenesis.

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Randomized trial analyzes miRNA expression in thyroid carcinomas, suggesting crucial roles in cancer development.

Pallante et al. (2006) studied this question.

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