Why the study?
Does sildenafil improve myocardial hypertrophy and function in rats with pressure-overloaded right hearts?
Does sildenafil improve myocardial hypertrophy and function in rats with pressure-overloaded right hearts?
In a rat model of right ventricular pressure overload, sildenafil improved RV contractile function despite increasing RV hypertrophy.
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Hypothesis-generating in RV pressure-overload models; does not support clinical use without prospective validation.
Andersen et al. (2008) studied this question.
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