Why the study?
Does rosiglitazone improve left ventricular contractility and reduce myocardial lipid accumulation in a canine model of chronic mitral regurgitation?
Population
Dogs with experimental chronic mitral regurgitation. Three groups: control animals, dogs with MR for 3…
Comparison
Rosiglitazone 8 mg/day for 3 months. vs Control animals without MR, and dogs with MR for…
Design
Preclinical
Follow-up
6 months (3 months of treatment)
Authors
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May support PPAR-gamma agonism in experimental MR; hypothesis-generating and should not yet change practice.
Does rosiglitazone improve left ventricular contractility and reduce myocardial lipid accumulation in a canine model of chronic mitral regurgitation?
In a canine model of chronic mitral regurgitation, the PPAR-gamma agonist rosiglitazone ameliorated LV contractile dysfunction and reduced intramyocyte lipid accumulation.
Nemoto et al. (2004) studied this question.