Why the study?
Does flecainide combined with propranolol prevent syncope and suppress arrhythmias in a pediatric patient with CPVT and RyR2 mutation?
Does flecainide combined with propranolol prevent syncope and suppress arrhythmias in a pediatric patient with CPVT and RyR2 mutation?
Flecainide combined with a beta-blocker effectively suppressed arrhythmias and prevented syncope in a pediatric patient with CPVT and an RyR2 mutation.
May support flecainide-propranolol in select pediatric CPVT; hypothesis-generating and requires prospective validation.
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Fukuoka et al. (2013) studied this question.
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