Combined ESR spin trapping and NMR spectroscopy demonstrates a significant correlation between oxy-radical formation and energy depletion during postischemic reperfusion in isolated hearts.
May link oxy-radical formation to energy loss in reperfusion; hypothesis-generating in isolated hearts, needs in vivo confirmation.
The relevance of radical formation in disturbances of energy metabolism in the postischemic heart is not clear. This study provides the first evidence of a significant correlation between the amount of oxy-radicals trapped in the effluent of isolated hearts upon reperfusion and the decreased myocardial content of phosphocreatine and ATP. This suggests that the loss of high-energy compounds might contribute to oxy-radical production during reperfusion. The application of ESR spin trapping and of NMR technique to the same heart is a new approach to investigate the pathobiochemical relevance of free radicals for the heart muscle.
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Blasig et al. (1990) studied this question.
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