December 1, 2001Journal of Biological ChemistryOpen Access

Prostacyclin-dependent Apoptosis Mediated by PPARδ

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Population

Human embryonic kidney 293 cells

Design

Preclinical

Authors

THToshihisa HataeInstitute of Applied Physics MWM. WadaNicolaus Copernicus Astronomical Center CYChieko YokoyamaWashington University in St. Louis

Discussion

Member takes

Implication

Should not alter clinical practice; leaves open intracellular prostacyclin-PPAR delta signaling as a cell-fate regulator for further validation.

Structured PICO

Population

Human embryonic kidney 293 cells

Intervention

Expression of prostacyclin synthase to form intracellular prostacyclin, treatment with extracellular prostacyclin, dibutyryl cAMP, or RpcAMP, and expression of L431A/G434A mutant of PPAR delta

Outcome

Apoptosis and PPAR delta activationsurrogate

Prostacyclin can act through endogenous PPAR delta as a second signaling pathway that controls cell fate, promoting apoptosis when formed intracellularly.

Cite This Study

Hatae et al. (2001) studied this question.

synapsesocial.com/papers/6a796d68b9dd6cc1fe0da2ae https://doi.org/10.1074/jbc.m107180200

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Implication

Should not alter clinical practice; leaves open intracellular prostacyclin-PPAR delta signaling as a cell-fate regulator for further validation.

Prostacyclin-dependent Apoptosis Mediated by PPARδ

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prostacyclin-dependent Apoptosis Mediated by PPARδ

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider