An efficient and facile method is used to develop new (salen)ruthenium(II) catalysts for the asymmetric cyclopropanation of olefins, in which a chiral additive induces asymmetry in inexpensive and readily synthesized achiral (salen)ruthenium(II) catalysts (see scheme; EDA=ethyl diazoacetate). This approach is amenable to parallel-screening optimization and has great potential advantages over traditional catalyst development and synthetic methods.
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Miller et al. (2005) studied this question.
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