Immunoglobulins in the Human Eye

Immunoglobulins were found in all structures of the eye except the lens. The highest concentrations (up to one-half the amount in serum) were found in the cornea, choroid, and conjunctiva. Moderate concentrations were found in the muscle and sclera. Low concentrations (less than 5% of the serum level) were found in the ciliary body, iris, aqueous, and retina. All five immunoglobulins and albumin were present in the immunoglobulin-containing tissues except for the cornea, which did not routinely contain IgM.