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January 1, 1991BloodOpen Access

Multiple in vivo effects of interleukin-3 and interleukin-6 on murine megakaryocytopoiesis

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Population

Mice (murine model)

Comparison

Human recombinant IL-6, murine recombinant IL-3… vs Control animals

Design

Preclinical

Follow-up

Up to 30 days

Authors

PCPA CarringtonUniversity of California, San FranciscoRHRJ HillMRC Laboratory of Molecular BiologyPSPE StenbergStanford University

Discussion

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Implication

Hypothesis-generating for IL-3/IL-6 in thrombopoiesis; leaves open human translation and rebound risks.

Structured PICO

P
Population
Mice (murine model)
I
Intervention
Human recombinant IL-6 (14 subcutaneous injections of 5,000 units each over 102 hours), murine recombinant IL-3 (8 injections of 80,000 units each over 54 hours), or a combination of both
C
Comparator
Control animals
O
Outcome
Megakaryopoiesis and thrombopoiesis (platelet levels, platelet production, megakaryocyte ploidy, colony-forming cells, megakaryocyte size) evaluated at 120 hours and up to 30 dayssurrogate

IL-6 and IL-3 stimulate platelet production in vivo with additive effects, followed by rapid reversal and rebound thrombocytopenia upon discontinuation.

Cite This Study

Carrington et al. (1991) studied this question.

synapsesocial.com/papers/6a7970122eb3c7e469f38b93https://doi.org/10.1182/blood.v77.1.34.bloodjournal77134
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Counts with the Coulter Counter1965 · 343 citations
  2. 2Stimulation of thrombopoiesis in mice by human recombinant interleukin 6.1990 · 145 citations