Why the study?
Zinc deficiency is a significant global health concern among children, manifesting in various acquired and inherited conditions with diverse clinical presentations, diagnostic challenges, and management strategies.
Highlights the diverse clinical manifestations of zinc deficiency in children and the need for a multidisciplinary approach to management.
May prompt consideration of zinc deficiency in children with dermatitis or growth issues; leaves open need for prospective validation before guiding practice.
Zinc deficiency is a significant global health concern among children, manifesting in various acquired and inherited conditions. This comprehensive overview of acquired and inherited zinc deficiency-related diseases in children aimed to explore the clinical presentations, diagnostic challenges, and management strategies associated with these conditions. This case series elucidates the diverse clinical manifestations of zinc deficiency in pediatric patients, ranging from dermatitis and growth retardation to immune dysregulation and neurological abnormalities, and discusses the underlying genetic mechanisms, clinical phenotypes, and therapeutic interventions. The complexity of zinc deficiency-related diseases in children underscores the need for a multidisciplinary approach involving pediatricians, dermatologists, geneticists, and nutritionists to optimize patient care and outcomes.
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Bellini et al. (2024) studied this question.
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