Screening of a Supramolecular Catalyst Library in the Search for Selective Catalysts for the Asymmetric Hydrogenation of a Difficult Enamide Substrate

Bindings for libraries: Large numbers of bidentate ligands have been formed from two monodentate ligands (one based on zinc(II) porphyrin and the other on a substituted phosphane) by using high-throughput methods combined with self-assembly principles. The library provided a Rh catalyst that hydrogenates the enamide 1 with the highest enantioselectivity known to date.