Why the study?
Does thrombolysis affect erythrocyte adenosine deaminase and lipid peroxidation levels in patients with myocardial infarction?
Does thrombolysis affect erythrocyte adenosine deaminase and lipid peroxidation levels in patients with myocardial infarction?
Elevated adenosine deaminase and malondialdehyde levels post-thrombolysis suggest a role for adenosine deaminase in myocardial ischemia-reperfusion injury.
May implicate adenosine deaminase in reperfusion injury post-MI thrombolysis; hypothesis-generating and should not change practice without prospective trials.
A comparative study on the levels of erythrocyte adenosine deaminase and lipid peroxidation has been undertaken in patients with myocardial infarction before and after thrombolysis along with matched healthy individuals. Our findings show that adenosine deaminase activity is highly elevated in post-reperfused patients when compared to pre- thrombolysed and healthy persons. Malondialdehyde(MDA) levels are also significantly increased in post-thrombolysed patients. The study reveals an important role of adenosine deaminase in reperfusion injury in patients with myocardial infarction.
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Kaul et al. (2006) studied this question.
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