Why the study?
Do the relative contributions of nitric oxide and prostaglandins to vasodilation differ between the endothelial agonists acetylcholine and bradykinin in healthy human limbs?
Population
50 healthy volunteers, mean age 27 +/- 1 years
Comparison
Brachial artery infusion of acetylcholine (ACh… vs Control condition
Design
Other
Authors
Loading...
Agonist-specific endothelial pathways in healthy limbs support mechanistic research; leaves open translation to disease or testing protocols.
Do the relative contributions of nitric oxide and prostaglandins to vasodilation differ between the endothelial agonists acetylcholine and bradykinin in healthy human limbs?
The mechanisms of endothelium-dependent vasodilation in human skeletal muscle vary by agonist, with acetylcholine relying more on nitric oxide and bradykinin relying more on endothelium-derived hyperpolarizing factor.
Schrage et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: