May 1, 2000AJP Cell Physiology

KChAP as a chaperone for specific K+channels

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Population

Xenopus oocytes and heart tissue

Design

Preclinical

Authors

YKYuri A. KuryshevCharles River Associates TGTatyana I. GudzMedical University of South Carolina ABArthur BrownRutgers, The State University of New Jersey

Discussion

Member takes

Implication

May modulate Ito in cardiomyocytes; leaves open effects on repolarization or arrhythmias in vivo.

Structured PICO

Population

Xenopus oocytes and heart tissue

Intervention

KChAP (and a 98-amino acid fragment)

Outcome

Amplitude of Kv1.3 and Kv4.3 currents and protein levelssurrogate

KChAP acts as a specific molecular chaperone for Kv1.3 and Kv4.3 channels, increasing their current amplitude and protein levels, which may be relevant for the transient outward current in cardiomyocytes.

Cite This Study

Kuryshev et al. (2000) studied this question.

synapsesocial.com/papers/6a7973b8fb5b6b43000db3e2 https://doi.org/10.1152/ajpcell.2000.278.5.c931

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KChAP as a chaperone for specific K+channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

KChAP as a chaperone for specific K+channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider