Why the study?
Despite reported benefits of SGLT2 inhibitors in heart failure, it is essential to investigate their adverse effects, including hypotension, volume depletion, and acute kidney injury.
Do SGLT2 inhibitors increase the risk of hypotension, volume depletion, and acute kidney injury in patients with heart failure?
Do SGLT2 inhibitors increase the risk of hypotension, volume depletion, and acute kidney injury in patients with heart failure?
In patients with heart failure, SGLT2 inhibitors are associated with a slightly increased risk of hypotension but do not increase the risk of volume depletion or acute kidney injury.
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Britto et al. (2024) studied this question.
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