Why the study?
Does correction of hypokalemia allow for safe retreatment with AMSA in a patient who previously developed ventricular fibrillation following AMSA?
Does correction of hypokalemia allow for safe retreatment with AMSA in a patient who previously developed ventricular fibrillation following AMSA?
A prior history of AMSA-induced cardiac arrhythmia does not contraindicate further treatment with AMSA if electrolyte balance, specifically hypokalemia, is corrected.
Hypokalemia correction may permit safe AMSA retreatment after prior VF; single case leaves open broader applicability.
A patient is presented who developed ventricular fibrillation following AMSA treatment, in the setting of hypokalemia. Resuscitation was successful, chemotherapy treatment response was observed, and further treatment with AMSA was uncomplicated after correction of the hypokalemia. With careful attention to electrolyte balance, a prior history of AMSA-induced cardiac arrhythmia does not contraindicate further treatment with AMSA.
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McLaughlin et al. (1983) studied this question.
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