What question did this study set out to answer?

To investigate cardiac mechanical work and energetics in Otsuka Long-Evans Tokushima Fatty rats to clarify the mechanisms underlying diabetic cardiomyopathy in type 2 diabetes.

January 1, 2002AJP Heart and Circulatory Physiology

Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats

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Authors

TATakehisa AbeHokkaido University Hospital YOYoshimi OhgaOkayama University NTNobuoki TabayashiNara Medical University

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Implication

Preserved energetics coupling in diabetic rat model; leaves open relevance to human diabetic cardiomyopathy.

Key Points

To investigate cardiac mechanical work and energetics in Otsuka Long-Evans Tokushima Fatty rats to clarify the mechanisms underlying diabetic cardiomyopathy in type 2 diabetes.
Evaluated left ventricular mechanical work, energetics, coronary blood flow, and coronary flow reserve in Otsuka Long-Evans Tokushima Fatty rats at different stages of type 2 diabetes.
Measured myocardial oxygen consumption associated with calcium handling during excitation-contraction coupling, mitochondrial oxidative phosphorylation, and basal metabolism.
Quantified membrane SERCA2 protein abundance and identified shifts in myosin isozymes (V1 to V3).
Systolic function, mean coronary flow, coronary flow reserve, and oxygen consumption for mechanical work were preserved in late diabetic rats despite a shift from V1 to V3 myosin isozymes.
Late diabetic rats demonstrated a significantly slower left ventricular relaxation rate (P < 0.05) and a reduced maximum pacing rate (falling from 300 to 240 beats/min).
Membrane SERCA2 protein levels were significantly reduced in severe diabetes (P < 0.001), decreasing oxygen consumption per minute for Ca2+ handling without altering basal metabolism or mitochondrial oxidative phosphorylation.

Cite This Study

Abe et al. (2002) studied this question.

synapsesocial.com/papers/6a797984fbd9051d3b0dc87c https://doi.org/10.1152/ajpheart.2002.282.1.h138

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Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats

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Implication

Key Points

Cite This Study

Left ventricular diastolic dysfunction in type 2 diabetes mellitus model rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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