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This review evaluates the role of lysosomal alkalinization in both neurodegenerative diseases and lysosomal storage disorders.

August 10, 2026Cell Communication and SignalingOpen Access

Lysosomal alkalinization: a convergent mechanism in lysosomal storage disorders and classical neurodegenerative diseases

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Authors

ADAnkur Rakesh DubeyIndian Institute of Technology Jodhpur SKSaurabh KumarNational Institute of Technology Agartala RSRuchira SinghUniversity of Rochester Medical Center

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Implication

Review identifies lysosomal alkalinization as a shared mechanism in neurodegenerative diseases and lysosomal storage disorders, suggesting therapeutic possibilities.

Key Points

This review evaluates the role of lysosomal alkalinization in both neurodegenerative diseases and lysosomal storage disorders.
Review of molecular mechanisms governing lysosomal pH regulation, focusing on vacuolar ATPases and ion channels.
Comparison of pathological outcomes from lysosomal alkalinization in neurodegeneration and lysosomal storage disorders.
Elevated lysosomal pH is linked to various neurodegenerative diseases, including Alzheimer's and Huntington's.
The review highlights common cellular defects caused by impaired lysosomal acidification.
This study suggests lysosomal pH is a potential therapeutic target for both neurodegenerative diseases and lysosomal storage disorders.

Cite This Study

Dubey et al. (2026) studied this question.

synapsesocial.com/papers/6a797d089c20a9bbd318410f https://doi.org/10.1186/s12964-026-03118-1

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Implication

Review identifies lysosomal alkalinization as a shared mechanism in neurodegenerative diseases and lysosomal storage disorders, suggesting therapeutic possibilities.

Lysosomal alkalinization: a convergent mechanism in lysosomal storage disorders and classical neurodegenerative diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Lysosomal alkalinization: a convergent mechanism in lysosomal storage disorders and classical neurodegenerative diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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